Biophysical Characterization of the hTERT Promoter DNA Structure

Event

When:
Fri, 30 Nov 2018, 03:00 pm - 04:00 pm
Where:
Natural Science Bldg. 112 - Louisville, KY
Category:
Fall 2018
Who:
Dr. Jonathan B. Chaires
Affiliation:
James Graham Brown Cancer Center

Description

Telomerase reverse transcriptase (hTERT) is the catalytic subunit of the enzyme telomerase that is essential for the maintenance of telomeres, the protective end-capping structures of chromosomes. Expression of the gene that codes for hTERT is controlled by a promoter region that contains a sequence that potentially forms a four-stranded G-quadruplex structure, a novel DNA form distinct from the canonical and well-known duplex DNA first described by Watson and Crick. This seminar will describe our biophysical and biochemical studies aimed at defining the details of G-quadruplex structure. Supported by NIH grant GM 077422.


Venue

Location:
Natural Science Bldg. 112